Primary Immunodeficiency (PI) is an umbrella term for more then 100 genetic defects that range widely in severity. PI affects males and females of all ages, but the most severe forms are detected most frequently in childhood. Symptoms of a PI disease are often overlooked because they appear to be common childhood illnesses such as sinus and ear infections, pneumonia, fever, and bronchitis. Thus, families and doctors are often unaware that the troubling conditions they are dealing with are actually rooted in a defect in the immune system and treat the symptoms rather than addressing the underlying cause. Failure to diagnose PI can lead to a life of serious chronic illness, permanent damage, or even death.

The majority of Primary Immune Deficiency patients are diagnosed with one of the following specific conditions. You can access more detailed information about them by clicking on the links below.

X-linked Hyper IgM Syndrome
Hyper IgM Immunodeficiency
Wiskott Aldrich Syndrome
Leukocyte Adhesion Deficiency
MHC Class II Deficiency
Complement Deficiencies
Chediak-Higashi Syndrome
CD40 Ligand